Xanthones—a natural substance in the mangosteen peel rich with benefits
Research on mangosteen peel enabled Associate Professor Dr. Suthasinee to discover xanthones, a substance in the flavanol group that is effective in combatting or halting various types of inflammation with anti-cancer, anti-bacterial, anti-allergy, anti-inflammatory, anti-microbial, anti-malarial and anti-oxidant qualities.
To investigate xanthones’ ability to reduce inflammation and destroy bacteria, a research project in collaboration with the Faculty of Medicine, Srinakharinwirot University, Thailand, was launched. The project aims to develop and extract xanthones in the form of hydroxyxanthones or HDX with the highest efficacy for the health of humans and animals.
“Extractions of mangosteen peels have brought about a variety of substances both beneficial and harmful. Moreover, they must go through a rather complicated process and we cannot control the quality of the extracts since it is dependent upon factors such as planting methods, use of fertilizer, climate, and care,” Associate Professor Dr. Suthasinee explained.
“We chose the method of analysis and sought to mimic the chemical structure of xanthones from mangosteen peels, giving us the desired essential extracts which are easier to apply directly as part of adjuvants in medicines, foods, and other products and to control their efficacy in the best manner possible.”
Leaky gut syndrome—a cause of disease in both humans and animals
Leaky gut syndrome can lead to many diseases, especially septicemia that can be hidden in human bodies. This happens when there is an abnormality in the functions of the intestines and the microvilli.
“If you can imagine how the cells in the microvilli work—they line up next to each other and are responsible for screening and controlling toxic substances, and bacteria that enter the bloodstream. When inflammation occurs, the cells cannot line up next to each other and function like a fortress, which makes it possible for toxic or foreign substances to enter the bloodstream. The condition is dangerous and must be treated before it is too late,” she explained.
A leaky gut does not always show any symptoms or if it does it could affect other physical ailments such as overtiredness, fatigue, headaches, or other body aches without any clear indication of the causes.
“The cause is not clear but hypothesized to be the result of stress. If the symptom occurs in human beings, they can consult physicians right away. However, if this occurs in animals, it is harder to tell if they are sick.”
Developing HDX into health products for humans and animals
This research is at the experimental stage to determine the quality of HDX’s performance. It has been used in pig farms first before being experimented on human beings and larger and more diverse types of animals. As Associate Professor Dr. Suthasinee concluded, “In the future, HDX will experiment in adjuvants in a variety of products like medicines and food items to improve the quality of life of both humans and animals.”
The research was published in the Journal of Functional Foods.
Wannaporn Chayalak et al, Hydroxyxanthone ameliorates IL1β-induced epithelial barrier disruption in colonic-like cells by down-regulation of p-MLC expression, Journal of Functional Foods (2021). DOI: 10.1016/j.jff.2021.104814
Replicating mangosteen peel extract as a treatment for intestinal inflammation in humans and animals (2022, September 5)
retrieved 6 September 2022
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.